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ABSTRACT Objective: Follicular thyroid carcinoma (FTC) is less frequent but has a worse prognosis than papillary carcinoma. The available evidence on pre-operative characteristics of FTC is controversial. Our objective was to characterize the clinical, ultrasound and histopathological presentation of FTC patients treated Chile. Subjects and methods: Retrospective analysis of 97 patients treated for FTC in 6 large centers in Chile. We analyzed their ultrasonographic features and classified the nodules according to ATA risk of malignancy and TI-RADS score, as well as the cytological findings according to the Bethesda system. We described their clinical and histopathological findings at diagnosis and classified their risk of recurrence and mortality according to ATA 2015 recurrence risk category and the eighth edition of the AJCC/UICC staging system, respectively. Results: Median age was 48 years and 73.2% were females. The median diameter was 38.8 mm; only 9.5% of them were microtumors. According to ATA risk of malignancy, 86% of the nodules were low or intermediate suspicious, while 78% were category 3 or 4A nodules according to the TI-RADS. Regarding the Bethesda system, 65.9% had indeterminate cytology (20.6% category III and 45.3% category IV). At histological examination, most were minimally-invasive and angio-invasive tumors with less than 4 foci (54.7% and 28.4% respectively). More than 90% of FTC were unifocal and there was no lymphovascular or extrathyroidal invasion or lymph node involvement. Four patients (4.1%) had distant metastases at diagnosis. Most patients (95%) had stage I or II disease according to the AJCC/UICC staging system, while the risk of recurrence was low at 51.5% when using the ATA risk of recurrence scale. Conclusions: At diagnosis, most FTCs were nodules of low or intermediate suspicion at ultrasound, nearly two thirds had indeterminate cytology according to the Bethesda system, and nearly 50% of them were of low risk of recurrence.

https://doi.org/10.20945/2359-3997000000580

Anthropometric Parameters, Lower Limb Functionality and Quality of Life After High-Intensity Interval Training in Healthy Young People Versus Older Adults
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Artigas-Arias, Macarena

; Olea, María Angélica

; San-Martín-Calísto, Yuri

; Huard, Nolberto

; Durán-Vejar, Fernanda

; Beltrán-Fuentes, Francisca

; Muñoz-Fernández, Aris

; Alegría-Molina, Andrea

; Sapunar, Jorge

; Salazar, Luis A

; Marzuca-Nassr, Gabriel Nasri

International Journal of Morphology

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Out 2021, Volume 39 Nº 5 Páginas 1337 - 1344

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

SUMMARY: The aim of this study was to determine the effects of High-intensity interval training (HIIT) on the quality of life in healthy young people (YNG) and older adults (OLD)and its correlation with physical health status (anthropometric parameters and lower limb functionality) YNG (21 ? 2 years, BMI 26.37 ? 2.69 n = 12) and OLD (67 ? 5 years, BMI 27.16 ? 3.04 n = 12) groups underwent 12weeks of HIIT. Before and after the HIIT, anthropometric assessments, lower limb functionality tests, and SF-36 quality-of-life questionnaire were performed. There were no significant changes in the SF-36 dimensions (P>0.05). After HIIT, there were improvement percentage changes in Mental Component Summary (MCS) (YNG, +8.51 ? 25.80 % vs. OLD, +2.30 ? 9.05 %) and in Physical Component Summary (PCS) (YNG, +2.66 ? 20.54 % vs. OLD, +4.34 ? 22.71 %). Negative correlations were observed between body mass index (BMI) with PCS (R=-0.570, P=0.009) and with MCS (R=-0.649, P=0.002) in OLD as well as between MCS and waist circumference (R=-0.557, P?0.001) in both groups. Also, correlations were observed between PCS and the sit-to-stand test (R=-0.424, P=0.006) in both groups and gait speed (R=0.458, P=0.042) only in YNG. HIIT promotes positive percentage changes in quality of life, with YNG showing better results in PCS and OLD in MCS. Quality of life and physical health status were correlated in both groups.

RESUMEN: Determinar los efectos del entrenamiento interválico de alta intensidad (HIIT) sobre la calidad de vida en jóvenes sanos (YNG) y personas mayores (OLD) y su correlación con el estado de salud física (parámetros antropométricos y funcionalidad de miembros inferiores). Ambos grupos, YNG (21 ? 2 años, IMC 26,37 ? 2,69 n = 12) y OLD (67 ? 5 años, IMC 27,16 ? 3,04 n = 12) realizaron 12 semanas de HIIT. Antes y después del HIIT, se realizaron evaluaciones antropométricas, pruebas de funcionalidad de miembros inferiores y cuestionario de calidad de vida SF-36. No hubo cambios significativos en las dimensiones del SF-36 (P >0,05). Después del HIIT, hubo cambios porcentuales de mejora en el componente sumario mental (MCS) (YNG, +8.51 ? 25.80 % vs. OLD, +2.30 ? 9.05 %) y el componente sumario física (PCS) (YNG, +2,66 ? 20,54 % vs. OLD, +2,30 ? 9,05 %), correspondientes a la calidad de vida. Se observaron correlaciones negativas entre el índice de masa corporal (IMC) con PCS (R=-0,570; P=0,009) y con MCS (R=0,649; P=0,002) en OLD, así como entre MCS y circunferencia de cintura (R = - 0,557, P?0,001) en ambos grupos. Además, se observaron correlaciones entre PCS y la prueba de sentarse y levantarse (R = -0,424; P = 0,006) en ambos grupos y la velocidad de la marcha (R = 0,458; P = 0,042) solo en YNG. HIIT promueve cambios porcentuales positivos en la calidad de vida, con YNG mostrando mejores resultados en PCS y OLD en MCS. La calidad de vida y el estado de salud física se correlacionaron en ambos grupos.

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Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil
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SAPUNAR, JORGE

; AGUILAR-FARÍAS, NICOLÁS

; NAVARRO, JUAN

; ARANEDA, GUSTAVO

; CHANDÍA-POBLETE, DAMIAN

; MANRÍQUEZ, VÍCTOR

; BRITO, ROBERTO

; CERDA, ÁLVARO

Revista médica de Chile

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Dez 2018, Volume 146 Nº 10 Páginas 1112 - 1122

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Background: Dyslipidemias in childhood increase the risk of cardiovascular events in adult life. Aim: To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents. Material and Methods: Cross-sectional study of 208 children aged 10.4 ± 1.0 years (107 women). Demographic data were obtained, and a clinical evaluation was conducted, including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure total cholesterol (CT), HDL cholesterol (cHDL) and triglycerides (TG), glucose and insulin. LDL cholesterol (cLDL), Non-HDL cholesterol and the indices CT/cHDL, cLDL/cHDL and AIP (log[TG/cHDL]) were calculated. Risk categories according to AIP for the pediatric population were also determined (low: AIP < 0.11, intermediate: AIP 0.11-0.21, high: AIP > 0.21). Results: Thirty eight percent of participants had dyslipidemia, without differences by gender and pubertal development. The frequency of dyslipidemia was significantly higher in children with obesity (54%, p < 0.01) and a waist circumference over percentile 90 (61%; p < 0.01). The later conditions had also higher CT/cHDL, cLDL/cHDL and AIP. According to AIP, 54% of children had a high atherogenicity risk along with alterations in anthropometric parameters and insulin resistance. All anthropometric and insulin resistance parameters were significantly correlated with the AIP. Conclusions: There is a high prevalence of dyslipidemia in the studied population, which is associated with an increased cardiometabolic risk. The indices of atherogenicity and particularly AIP are correlated with nutritional status, abdominal obesity and parameters of insulin resistance.

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Rol de la cirugía bariátrica/metabólica en el manejo de la diabetes mellitus 2. Consenso SOCHED/SCCBM
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SAPUNAR, JORGE

; ESCALONA, ALEX

; ARAYA, A. VERÓNICA

; AYLWIN, CARMEN GLORIA

; BASTÍAS, MARÍA JULIANA

; BOZA, CAMILO

; CÁRCAMO, CARLOS

; CSENDES A, ATTILA

; DAVIDOF F, PATRICIO

; FUNKE, RICARDO

; GÓMEZ, PATRICIA

; GONZÁLEZ, MARÍA ISABEL

; LAHSEN, RODOLFO

; LANZARINI, ENRIQUE

; MAÍZ, ALBERTO

; MUJICA, VERÓNICA

; MUÑOZ, RODRIGO

; PÉREZ, GUSTAVO

; RAIMANN, FÉLIX

; SALMAN, PATRICIO

; SEPÚLVEDA, MATÍAS

; SOTO, NÉSTOR

; VILLAGRÁN, RODRIGO

Revista médica de Chile

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Dez 2018, Volume 146 Nº 10 Páginas 1175 - 1183

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Diabetes Mellitus (DM) and obesity are a public health problem in Chile. Bariatric surgery is the most effective treatment alternative to achieve a significant and sustained weight reduction in patients with morbid obesity. The results of controlled clinical trials indicate that, compared to medical treatment, surgery for obese patients with DM2 allows a better control of blood glucose and cardiovascular risk factors, reduces the need for medications and increases the likelihood for remission. Consensus conferences and clinical practice guidelines support bariatric surgery as an option to treat DM2 in Class III Obesity (Body Mass Index (BMI) > 40) regardless of the glycemic control and the complexity of pharmacological treatment and in Class II Obesity (BMI 35-39,9) with inadequate glycemic control despite optimal pharmacological treatment and lifestyle. However, surgical indication for patients with DM2 and BMI between 30-34.9, the most prevalent sub-group, is only suggested. The Chilean Societies of Endocrinology and Diabetes and of Bariatric and Metabolic Surgery decided to generate a consensus regarding the importance of other factors related to DM2 that would allow a better selection of candidates for surgery, particularly when weight does not constitute an indication. Considering the national reality, we also need a statement regarding the selection and characteristics of the surgical procedure as well as the role of the diabetologist in the multidisciplinary team.

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Estrés psicológico y síndrome metabólico
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Ortiz, Manuel S.

; Sapunar, Jorge

Revista médica de Chile

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Nov 2018, Volume 146 Nº 11 Páginas 1278 - 1285

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Background: Psychological stress and depressive symptoms are variables associated with metabolic syndrome (MetS). Aim: To determine the longitudinal association between psychological stress, depressive symptoms and MetS, and whether these variables predict MetS and its component trajectories. Material and Methods: Four hundred and twenty-three participants aged 44 ± 9 years (59% women), free of cardiovascular disease at baseline were enrolled into the Chilean study of psychological stress, obesity and MetS. Participants were followed-up for three years (three waves). Each year, they completed psychological questionnaires, anthropometric variables were measured, and blood samples were obtained. Results: Hierarchical linear regression showed that chronic psychological stress at baseline predicted the total number of MetS components (MetS score) during the third assessment wave (β = 0.147; p < 0.01). Growth curve modeling allowed to determine that participants who scored +1 standard deviation (SD) at baseline over the mean in psychological stress (βchronic stress = 0.903; 95% confidence intervals (CI) = 0.065; 1.741), and depressive symptoms (βdepressive symptoms = 2.482; 95% CI = 0.040; 4.923) had a higher waist circumference trajectory, as compared to those scoring −1 SD above the mean. Conclusions: Chronic psychological stress is longitudinally associated with the MetS score. Further, psychological stress and depressive symptoms at baseline predicted elevated MetS score trajectories, and a highest waist circumference.

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Alta prevalencia de trastornos nutricionales por exceso, resistencia insulínica y síndrome metabólico en escolares de la comuna de Carahue, Región de la Araucanía
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Sapunar, Jorge

; Aguilar-Farías, Nicolás

; Navarro, Juan

; Araneda, Gustavo

; Chandia-Poblete, Damian

; Manríquez, Víctor

; Brito, Roberto

; Cerda, Alvaro

Revista médica de Chile

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Set 2018, Volume 146 Nº 9 Páginas 978 - 986

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Background: Childhood and adolescent obesity is a major public health problem in Chile. Aim: To characterize cardiometabolic risk factors in a population of schoolchildren from Carahue, Chile. Material and Methods: Cross-sectional assessment of 208 children aged 10.4 ± 1.0 years (106 women). A clinical evaluation was carried out including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure glucose, insulin and lipid profile. HOMA-IR and Quicki indices were calculated. Insulin resistance (IR) was established according to Burrows criteria and Barja criteria, previously proposed for the Chilean pediatric population. The metabolic syndrome (MetS) was established using the modified Cook criteria. Results: Thirty eight percent of children had overweight and 33.1% obesity. MetS was only observed in obese subjects and the frequency in this subgroup was 38%. The prevalence of IR was 51% according to the Burrows criteria and 19% according to Barja criteria. It was more common in participants who were overweight, obese or had abdominal obesity. Children with insulin resistance according to Barja criteria, had worse anthropometric measures than their counterparts without resistance. When Burrows criteria was used, no differences in anthropometric measures were observed between participants with or without resistance. The frequency of MetS was 26 and 18% in children with insulin resistance according to Barja and Burrows criteria, respectively. Insulin levels and insulin sensitivity indexes were positively correlated with anthropometric parameters. Conclusions: There was a high prevalence of overweight, obesity and MetS in these participants. Our results suggest that the IR criteria according to Barja allows to identify cases with higher metabolic risk.

https://doi.org/10.4067/s0034-98872018000900978 2428 downloads

Análisis crítico del tratamiento de la enfermedad hepática grasa no alcohólica
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Lanuza, Fabian

; Sapunar, Jorge

; Hofmann, Edmundo

Revista médica de Chile

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Ago 2018, Volume 146 Nº 8 Páginas 894 - 901

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Non-alcoholic fatty liver disease (NAFDL) includes fatty liver or simple steatosis, characterized by lipid deposits in hepatocytes and more advanced stages such as steatohepatitis (NASH) and non-alcoholic cirrhosis. Physical inactivity, hypercaloric and unbalanced diet together with aging play a key role in the pathogenesis of NAFLD and are strongly associated with metabolic and physical activity continue to be major components in prevention and first-line treatment to attenuate or reverse NAFLD. Dietary patterns, their composition and weight reduction would be the most relevant nutritional aspects in NAFDL treatment. Physical exercise, moderate to intense, aerobic and resistance type contributes to weight loss, improves metabolic control and body composition. Pharmacological therapy can be useful in clinical circumstances that require it and needs a medical evaluation when there is no adherence and success in non-pharmacological interventions.

https://doi.org/10.4067/s0034-98872018000800894 6672 downloads

II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina
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Pollak, Felipe

; Araya, Verónica

; Lanas, Alejandra

; Sapunar, Jorge

; Arrese, Marco

; Aylwin, Carmen Gloria

; Bezanilla, Carmen Gloria

; Carrasco, Elena

; Carrasco, Fernando

; Codner, Ethel

; Díaz, Erik

; Durruty, Pilar

; Galgani, José

; García, Hernán

; Lahsen, Rodolfo

; Liberman, Claudio

; López, Gloria

; Maíz, Alberto

; Mujica, Verónica

; Poniachik, Jaime

; Sir, Teresa

; Soto, Néstor

; Valderas, Juan

; Villaseca, Paulina

; Zavala, Carlos

Revista médica de Chile

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Mai 2015, Volume 143 Nº 5 Páginas 627 - 636

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Insulin resistance is a prevalent condition commonly associated with unhealthy lifestyles. It affects several metabolic pathways, increasing risk of abnormalities at different organ levels. Thus, diverse medical specialties should be involved in its diagnosis and treatment. With the purpose of unifying criteria about this condition, a scientific-based consensus was elaborated. A questionnaire including the most important topics such as cardio-metabolic risk, non-alcoholic fatty liver disease and polycystic ovary syndrome, was designed and sent to national experts. When no agreement among them was achieved, the Delphi methodology was applied. The main conclusions reached are that clinical findings are critical for the diagnosis of insulin resistance, not being necessary blood testing. Acquisition of a healthy lifestyle is the most important therapeutic tool. Insulin-sensitizing drugs should be prescribed to individuals at high risk of disease according to clinically validated outcomes. There are specific recommendations for pregnant women, children, adolescents and older people.

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Efecto del estado nutricional neonatal en el riesgo de síndrome metabólico en niños obesos de 2 comunas de la Región del Bío-Bío
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Sapunar, Jorge

; Bustos, Paulina

; Sáez, Katia

; Muñoz, Sergio

; Asenjo, Sylvia

Revista médica de Chile

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Dez 2014, Volume 142 Nº 12 Páginas 1523 - 1529

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Background: Neonatal malnutrition defined by birth weight (BW) is a risk factor for obesity and cardio-metabolic diseases in adults. Neonatal ponderal index (NPI) may have better diagnostic value than BW to establish nutritional status. Aim: To determine the effect of neonatal nutritional status, established by the three NPI curves available in Chile, on the risk of Metabolic Syndrome (MS) in obese school children. Material and Methods: A nested case/control study in a sample of 410 obese school children aged 10 to 16 years (57% males) was performed. The dichotomous response variable was the presence of MS defined as International Diabetes Federation (IDF) or Cook’s criteria. The exposure variable was having NPI < percentile (p) 10. Results: The frequency of MS was 36 and 39% according to the IDF and Cook criteria, respectively. The proportion of children with neonatal malnutrition exceeded 20%. A significantly increased risk for MS was only found when PNI was defined according to Lagos´s Table and MS was defined using IDF criteria. Having a PNI > p90, however, showed a trend towards a reduced risk of MS, which only reached significance using Lagos´s Table and Cook´s Criteria. Conclusions: Neonatal malnutrition defined by NPI is common in obese school children. The condition of neonatal under nutrition defined as PNI < p10 may be a risk factor for developing MS. Instead, having a NPI > p90 could be protective.

2595 downloads

10.

Ejercicio físico interválico de alta intensidad mejora el control glicémico y la capacidad aeróbica en pacientes con intolerancia a la glucosa
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Mancilla, Rodrigo

; Torres, Paola

; Álvarez, Cristian

; Schifferli, Ingrid

; Sapunar, Jorge

; Díaz, Erik

Revista médica de Chile

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Jan 2014, Volume 142 Nº 1 Páginas 34 - 39

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Background: Proper exercise training modifies intra miocellular energy utilization, glucose transport and mitochondrial biogenesis. Aim: To determine the therapeutic effects of a high intensity intermittent training (HIIT) program on glucose homeostasis, physical fitness and body fat in glucose intolerant patients. Patients and Methods: Eighteen patients with overweight or obesity and glucose intolerance were invited to participate in an exercise program consisting in three sessions per week for 3 months. Ten participants aged 35 ± 13 years who attended > 26 of the planned 36 sessions, were considered as adherent to exercise. The other eight participants aged 37 ± 17 years, who attended to a mean of 13 sessions, were considered as non-adherent. Both groups had similar body weight, body mass index, body fat, plasma glucose 2 h after an oral glucose load and maximal oxygen uptake. All these variables were measured at the end of exercise intervention. Each session consisted of 1 min exercise of cycling at maximal intensity until muscle fatigue followed by 2 min rest, repeated 10 times. Results: Among adherent participants, twelve weeks of HIIT improved signifcantly maximal oxygen uptake (6.1 + 3.6 mL/kg/min or 24.6%), reduced 2 h post load blood glucose (-33.7 + 47.9 mg/dL or -12.5%) and body fat (-4.3 + 5.6 kg). No signifcant changes were observed in the non-adherent group. Conclusions: HIIT exercise reduces blood glucose after an oral load in glucose intolerant patients.

42261 downloads Citado 8 vezes em SciELO

11.

Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén
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Orellana, Gloria

; Sapunar, Jorge

; Sáez, Katia

; Aguayo, Claudio

; Calvo, Carlos

; Radojkovic, Claudia

; Riffo, Benilde

; Gleisner, Andrea

; Asenjo, Sylvia

; Ulloa, Natalia

Revista médica de Chile

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Out 2012, Volume 140 Nº 10 Páginas 1245 - 1252

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Background: Several genetic polymorphisms of adiponectin have been associated to metabolic diseases as obesity and co-morbidities. Aim: To investigate if there are associations between +45TG, +276GT, -11,377CG y -11,391GA adiponectin SNPs (single nucleotide polymorphism) with obesity in a Chilean children population. Material and Methods: A case-control study was performed in 241 obese and 126 normal weight children (7-11 years old) from the urban community of Hualpén, Biobío region. Children were classified as normal or obese, according to age and gender-specificpercentiles defined by Centerfor Disease Control and Prevention (CDC). The analysis of serum markers was carried out using commercial kits. Adiponectin polymorphisms were determined through a High Resolution Melting (HRM)-enabled real time PCR and by DNA fragment sequencing. Results: The observed allelic frequencies of the studied SNPs were over 11%. The 11,377CG polymorphism was associated with a high risk of obesity, calculated by the additive inheritance model (odds ratio = 1.389, 95% confidence interval: 1.001-1.929,p = 0.049). Conclusions: Obese school children of the Biobío Region, have an increased risk of carrying the susceptibility allele polymorphism 11377CG of adiponectin gene.

7162 downloads Citado 1 vez em SciELO

12.

Epidemiología del sobrepeso y obesidad infanto-juvenil en las comunas de Concepción, Coronel y Hualpén, VIII Región de Chile
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ULLOA, NATALIA

; SAPUNAR, JORGE

; BUSTOS, PAULA

; SÁEZ, KATIA

; ASENJO, SYLVIA

; TAIBO, MARCELA

; CORNEJO, AMALIA

Revista médica de Chile

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Nov 2010, Volume 138 Nº 11 Páginas 1365 - 1372

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Background: The frequency of obesity is increasing steadily in Chile. Aim: To assess the prevalence of obesity and overweight in children and teenagers living in three southern Chilean cities. Material and Methods: The database of an evaluation performed in 2006 in schools, was used to obtain weight and height of 32514 subjects aged 12 ± 4 years (48% males). Criteria proposed by the International Obesity Task Force (IOTF) and the Centers for Disease Control (CDC) were used to define obesity and overweight. Results: According to CDC criteria the prevalence of overweight and obesity was 11.2% and 6.5%, respectively. According to IOTF criteria, the fgures were 13.2 and 4%, respectively. The higher frequency of overweight and obesity was observed among children aged less than eight years. Conclusions: There is a high frequency of obesity and overweight in the studied sample.

12470 downloads Citado 5 vezes em SciELO

13.

Congenital Chagas disease of second generation in Santiago, Chile. Report of two cases
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SCHENONE, Hugo

; GAGGERO, María

; SAPUNAR, Jorge

; CONTRERAS, María del C.

; ROJAS, Antonio

Revista do Instituto de Medicina Tropical de São Paulo

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Ago 2001, Volume 43 Nº 4 Páginas 231 - 232

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Congenital Chagas disease (CChD) has been reported in different countries, mostly in Latin America. In 1987 a fatal case of CChD of second generation (CChDSG) was published. Within a period of six months - 1989-1990 - two cases of CChDSG were diagnosed and studied in the city of Santiago. Two premature newborns, sons of two sisters, with moderate liver and spleen enlargement, were found to have positive serology for Chagas disease and xenodiagnoses. The mothers, urban residents all their lives, without antecedents of triatomine bugs contact or blood transfusions, showed positive serology and xenodiagnoses. Their mother (grandmother of the infants), lived 20 years in a Northern rural Chagas disease endemic locality, in a triatomine infested house. Afterwards, she moved to Santiago, where she married and has resided up to now. Serology and xenodiagnoses were also positive. All the Trypanosoma cruzi infected individuals were successfully treated with nifurtimox.

La enfermedad de Chagas congénita ha sido reportada en diferentes países, en su gran mayoría de Latinoamérica. En 1987 un caso fatal de enfermedad de Chagas congénita de segunda generación fue publicado. En 1989-1990 dos casos de enfermedad de Chagas congénita de segunda generación fueron diagnosticados y estudiados en la ciudad de Santiago. Dos recién nacidos prematuros, hijos de dos hermanas, con moderado aumento del hígado y del bazo, presentaron serología para enfermedad de Chagas y xenodiagnósticos positivos. Las madres, residentes urbanas toda su vida, sin antecedentes de contacto con triatominos ni transfusiones de sangre presentaron serología y xenodiagnósticos positivos. La madre de ellas (abuela de los niños) nació y vivió 20 años en una localidad rural de endemia chagásica, en una casa infestada con triatominos. Posteriormente, se trasladó a vivir a Santiago, donde se casó y ha residido hasta el presente; su serología y xenodiagnóstico fueron positivos. Todas las personas infectadas con Trypanosoma cruzi fueron tratadas exitosamente con nifurtimox.

2063 downloads Citado 1 vez em SciELO

14.

Fascioliasis hepática que simularon tumores hepáticos
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Sapunar, Jorge

; Braghetto, Italo

; Díaz, Juan Carlos

; Brahm, Javier

; Apt, Werner

; Carreño, Laura

; Poniachick, Jaime

Boletín chileno de parasitología

Métricas do periódico
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Jul 2001, Volume 56 Nº 3-4 Páginas 59 - 65

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Two cases of hepatic fascioliasis which simulated hepatic tumors are presented: Patient 1. (42-year-old woman), presented pain in the epigastric and right hypochondrium. US, CAT and MNR suggested a cholangiocarcinoma. She was operated on by practicing hepatic segmentectomy, cholecystectomy and closign of a cholecystogastric fistula. The extirpated hepatic segment presented a tumoral aspect, but its histopathological study revealed numerous granulomas, some of them with F. hepatica eggs and others with Charcot - Leyden crystals. ELISA and complement fixation reaction for fascioliasis resulted positive. Search of F. hepatica eggs in stools was negative. The patient was treated with triclabendazole. Patient 2. (58-year-old woman) also presented pains in the upper hemiabdomen. Hypereosinophilia (32%). Abdominal CAT showed multiple hipondense irregular zones suggesting infiltrative processes in the liver right lobe. The hepatic biopsy, under CAT, eventhough lead to think in a hamartoma, a diagnosis of chronic cholangitis compatible with a parasitic etiology raised. ELISA and complement fixation reaction for fascioliasis were positive. Coproparasitological exams for F. Hapatica resulted negative. She was successfully treated with triclabendazole. Hapatic fascioliasis simulates numerous diseases, among them hepatic tumors.

8943 downloads Citado 2 vezes em SciELO

15.

Hidatidosis del omóplato con localización extraósea
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Sapunar, Jorge

; Velasco, Marta

Boletín chileno de parasitología

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Jul 2000, Volume 55 Nº 3-4 Páginas 65 - 69

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

A forty three-year-old female, born in a rural area of southern Chile, at the age of 30 presented pain and limitation of motility of the right shoulder. Later on, she presented an increasing of volume at the right scapular region. A radiography showed an osteolytic lesion of the scapula. In a biopsy an osseous hydatidosis was found and a hydatid cyst was extirpated from the soft tissues. Four years later, as she presented again pain and volume increasing in the same anatomical area, albendazole was given to her, and a CAT practiced revealed osteolytic lesions of the bone, several periosteal ruptures and multiple cysts in the muscles. She was submitted to surgery again in order to extirpate cysts. After two years the patient presented the same clinical manifestations and radiological and CAT images previously observed. In considering all these facts a radical surgery was decided.

13859 downloads Citado 3 vezes em SciELO

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